【Objective】The purposes of this research were to (i) reduce or slow down the release and conversion rate of nitrogen, (ii) increase the utilization rate of nitrogen, (iii) increase the yield of wheat, and (iv) reduce environmental pollution.【Method】We applied the coating technology and inhibitor addition technology at the same time to prepare a new type of dual controlled release urea. For preparation, the coating material of the controlled release fertilizer was natural rubber while the inhibitors used were urease inhibitor (NBPT, n-butyl thiophosphoric triamide) and nitrification inhibitor (DMPP, 3,4-dimethylpyrazole phosphate). According to the different inhibitors added, four kinds of new natural rubber coated urea were prepared: uncoated (CRU1), NBPT coating (CRU2), DMPP coating (CRU3), and (NBPT+DMPP) combined coating (CRU4). The microstructure of natural rubber coated urea was observed by a scanning electron microscope (SEM). The slow-release characteristics of urea nitrogen were determined using a hydrostatic release test. The effects of NBPT and DMPP in controlling nitrogen conversion were determined by soil culture test. Also, we designed field experiments to verify the effects of the four controlled-release urea on soil nitrogen supply and winter wheat growth. 【Result】Natural rubber was used as a membrane material to prepare controlled-release fertilizers, with good film-forming properties, smooth surface and obvious nutrient channels in the profile. When loaded in still water, the controlled release period of natural rubber coated controlled-release fertilizer reached 60 days. Compared with urea (U) treatment, all controlled-release fertilizers significantly reduced the ammonia volatilization rate in the soil and postponed the peak ammonia volatilization days. Also, CRU1, CRU2, CRU3, and CRU4 significantly increased the continuous nitrogen supply capacity of the soil and increased the yield of wheat under 10% nitrogen reduction relative to U treatment. CRU4 was better than adding NBPT and DMPP alone in reducing soil urease activity during the growth period of winter wheat, inhibiting the conversion of soil NH4+-N to NO3--N, and reducing soil ammonia volatilization. Relative to U treatment, winter wheat production of CRU1, CRU2, CRU3, and CRU4 increased by 16.96%, 21.46%, 17.37% and 25.90%, respectively. 【Conclusion】CRU4 demonstrated the strongest continuous nitrogen supply capacity when applied in soil and the best increase in winter wheat yield. This result indicates that the new controlled-release urea prepared by combining natural rubber and inhibitor-coated urea controlled the dissolution of urea and delayed the urea conversion process. Under the condition of a 10% reduction in nitrogen application rate, the yield of winter wheat can still be significantly increased.