This paper deals maiilly with the relationship between Pb and Cd pollution and enayme activities of soil in wastewater irrigated area of Banding city.The results show that the contents of Pb and Cd in soils of wastewater irrigated area were higher than those in soils irrigated with fresh water and exceeded the standards of soil background values for some cities at home and abroad,and the contents of Pb and Cd in soils of wastewater irrigated area approched or reached the lightly polluted levels.There appeared a close relationship between heavy metal pollution and enzyme activity.The soil unease and catalase activities decreased evidently with increasing contents of Pb and Cd.According to the regressive fitting results there existed a very significant exponential negative correlation between soil unease and catalase activities and Pb and Cd contents with the maximum r² model equation of y=axe^-bx band the correlation coefficients (r) of -0.804^**,-0.795^** and -0.899^**,-0.852^**,respectively.It is feasible to use soil unease and catalase activities as primary biochemical indexes to evaluate Pb nd Cd pollution in soils of the wastewater irrigated area.