[Objective] To explore roles of ferulic acid, a phenolic-acid-like autotoxic substance, in occurrence of a hazard to monocropping of faba bean, mechanism of ferulic acid promoting faba bean Fusarium wilt and effects of interplanting of wheat with faba bean alleviating ferulic acid stress, a field experiment was carried out.[Method] In the experiment faba bean was interplanted with wheat. Effects of the interplanting were investigated on occurrence of fusarium wilt, activities of root cell wall degrading enzymes (pectinase, cellulase, protease and amylase), lignin content, callose deposition and root ultrastructure in the presence of Fusarium oxysporum f. sp. fabae (FOF) and under the stress of ferulic acid varying in concentration (0, 50, 100 and 200 mg·L^-1).[Result] Results show that in the monocropping group, compared with the controls (without ferulic acid stress), all the ferulic acid treatments, regardless of concentration, significantly increased incidence and index of the disease, activities of the cell wall degrading enzymes, lignin content and callose deposition, thus leading to distortion of cell structure, leakage of intracellular substances and worsening of the resistance of root tissue structure, which indicates that the synergistic effect of ferulic acid and the pathogen aggravated the hazard to monocropping of faba bean., while compared with the monocropping treatments, the interplanting treatments, though under the stress of 0-200 mg·L^-1 ferulic acid, decreased incidence of the disease by 0.0%-31.7%, disease index by 28.3%-46.9%, root pectinase activity by 17.9%-60.1%, cellulase activity by 1.2%-28.2%, protease activity by 5.6%-60.3% and amylase activity by 16.8%-65.5%, but increased lignin content by 9.8%-57.7%, and reduced callose deposition, thus ensuring normal transportation of nutrients and alleviating deformation of cell structure. Intracellular substances of root cells, like membrane, nucleus and organelle, of the faba plants in the interplanting treatments were less damaged. Obviously the plants effectively prevented further invasion of FOF, reduced the damage of Fusarium wilt, and ensured normal growth of faba bean. The field experiment demonstrates that wheat and interplanting of faba bean with wheat can significantly reduce the damage of Fusarium wilt to the bean crop.[Conclusion] All the findings in this experiment suugest that faba been interplanted with wheat can improve the resistance of faba against FOF under ferulic acid sterss. Therefore, the practice of interplanting can be adopted as an effective strategy for management of Fusarium wilt of faba bean.