西南某矿区土壤重金属的人体生物有效性及健康风险评估研究
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1.西南林业大学;2.云南师范大学

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国家重点研发计划项目(2018YFC1800504);云南省创新团队项目(202005AE160017);国家自然科学基金项目(41967026);国家林业和草原局林草科技创新青年拔尖人才项目(2020132613);云南省高层次人才引进计划青年人才项目(YNQR-QNRC-2018-049);云南省教育厅科学研究基金项目资助(2021Y231, 2021Y237)


Human bioavailability and health risk assessment of heavy metals in soils of a mining area of southwest China
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Affiliation:

1.Southwest Forestry University;2.Yunnan Normal University,;3.yunnan Normal University

Fund Project:

Supported by the National Key Research and Development Program of China (2018YFC1800504), the Yunnan Innovative Research Team (202005AE160017), the National Natural Science Foundation of China (41967026), the Scientific and Technological Innovation Top Young Talents Project of National Forestry and Grassland Administration (2020132613), the Yunnan Thousand Youth Talent Program (YNQR-QNRC-2018-049), and the Research Foundation of Yunnan Education Department (2021Y231, 2021Y237)

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    摘要:

    近年来,利用生物可给性修正土壤重金属经口摄入对人体的健康风险频见报道,然而生物可给性往往会高估其健康风险。利用体内实际摄入剂量(生物有效性)作为健康风险评价指标将更为准确,然而基于生物有效性的矿区场地土壤重金属污染健康风险评估仍然鲜有报道。因此本研究以云南文山某矿区为研究对象,分析了5个土壤样点中Cd、Pb、Zn和Cu的含量,通过体外消化法(SBRC)测定了4种重金属的生物可给性,并结合Balb/c小鼠实验分析了重金属Cd的相对生物有效性(RBA),基于此探究该矿区土壤重金属Cd、Pb、Zn和Cu对人体产生的健康风险。结果表明,该矿区土壤Cd污染较为严重,含量为2.06 mg·kg?1。四种重金属的生物可给性在胃相中的范围分别为24.29~50.55%、7.68~17.87%、24.61~32.18%、7.75~37.87%,在肠相中分别下降到22.78~44.32%、1.64~5.22%、14.10~28.11%、8.51~31.49%。动物实验测得的Cd在肝脏中RBA为1.31~48.39%,肾脏中为2.83~8.58%,肝和肾复合器官中为4.60~50.95%,且肝和肾复合器官是测定Cd-RBA较为理想的靶器官。基于目标重金属总量、生物可给性和生物有效性对该场地土壤进行的健康风险评估可得出,利用重金属总量的评估风险过高,而基于生物可给性和生物有效性的数据发现显著降低了人体的健康风险。综上,基于土壤中重金属总量的健康风险可能存在高估现象,建立基于人体生物有效性的健康风险评估方法将更为准确。

    Abstract:

    Recently, the bioaccessibility has been frequently employed to assess the human health risks of oral exposure to heavy metals in soi. However, thebioaccessibility of heavy metals in soils from in vitro gastrointestinal simulation may overestimate their human health risk. Bioavailability, the fraction of heavy metals that reaches the systemic circulation, is considered as an accurate approach to evaluate the potential health risk of contaminants. However, there are few studies on health risk assessment of soils heavy metals from mining sites via bioavailability. Therefore, in this study, five soil samples form mining area of Wenshan, Yunnan Province were collected and the contents of Cd, Pb, Zn and Cu were analyzed using ICP-MS. The bioaccessibility of four heavy metals were detected by in vitro digestion method (SBRC), while the relative bioavailability of heavy metals Cd was determined using Balb/c mice models. The results showed that the soil Cd pollution in this mining area was serious, and the content of Cd was 2.06 mg·kg?1. The bioaccessibility of the four heavy metals in the gastric phase was 24.29~50.55%, 7.68~17.87%, 24.61~32.18%, 7.75~37.87%, respectively. In intestinal phase, they were 22.78~44.32%, 1.64~5.22%, 14.10~28.11%, 8.51~31.49%, respectively. The RBA of Cd measured in vivo was 1.31~48.39% in liver, 2.83~8.58% in kidney, and 4.60~50.95% in liver and kidney, which were ideal target organs for the determination of Cd-RBA. Health risk assessment of the mining soil based on the target heavy metal, bioaccessibility and bioavailability revealed that the assessment risk using the heavy metal aggregates was too high, while the data based on bioaccessibility and bioavailability found that the human health risk was significantly reduced. In conclusion, health risks assessment based on the total amount of heavy metals in soil may be overestimated, and establishment of a new method based on the bioavailability data will be more accurate.

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保欣晨,马娇阳,徐武美,王豪吉,王成尘,向萍.西南某矿区土壤重金属的人体生物有效性及健康风险评估研究[J].土壤学报,,[待发表]
bao xin chen, ma jiao yang, xu wu mei, wang hao ji, wang cheng chen, xiang ping. Human bioavailability and health risk assessment of heavy metals in soils of a mining area of southwest China[J]. Acta Pedologica Sinica,,[In Press]

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