【Objective】The sustainable and safe utilization of agricultural soil is of great significance to effectively improve the quality of the agricultural soil environment, and to ensure the quality and safety of agricultural products and human health.【Method】Taking Zhejiang Province, one of the most developed areas in the Yangtze River Delta, as an example, the main problems and development trends of agricultural land soil environment were analyzed, and the theory and method of sustainable and safe utilization of agricultural land soil were studied. During the 13th Five-year Plan period, based on the survey results of agricultural land soil pollution in Zhejiang Province at a scale of 1: 50 000 over the years, provincial pilot demonstrations focusing on the control of heavy metal cadmium pollution in agricultural land were carried out in Wenling City and Tonglu County. The methods of pollution source analysis and prevention, multi-dimensional agricultural safety utilization technology screening and application, and safe disposal of over-standard crop straws were comprehensively adopted to form a batch of agricultural land soil pollution comprehensive treatment technology models with significant regional characteristics, high-efficiency control effects, and independent intellectual property rights, which are suitable for mild to moderate and moderate to severe cadmium pollution.【Result】The main results were as follows: (1)Atmospheric deposition source is one of the main external input sources of Cd in the agricultural land ecosystem, accounting for about 24%-59% of the total input.(2)58 varieties with low accumulation(mainly Yongyou 538)were screened out, 20 passivation materials with calcareous substances as the main, and 10 leaf resistance control materials with silicon and selenium as the main were selected.(3)The safe utilization technology mode of rice/wheat rotation, which is suitable for light and moderate Cd polluted agricultural land can effectively reduce the available state of Cd in soil by more than 20%-50%. The production and remediation technology mode which is suitable for moderate and severe Cd polluted agricultural land, mainly with hyperaccumulators, can effectively reduce the total amount of Cd in soil by more than 30% and the available state of Cd in soil by more than 50%.【Conclusion】This paper innovatively puts forward the general idea and technical route of sustainable and safe utilization of heavy metal polluted agricultural land soil. It also summarizes the experience and strategy of sustainable and safe utilization of heavy metal polluted agricultural land soil, to provide a demonstration model and technical reference for the safe utilization of contaminated agricultural land soil in China.