The investigation on the salt tolerance of potato grown on sand dunes and its management with saline water drip irrigation was carried out in the Negev Experimental Station for Saline Water Irrigation from Feb. to Jul. 1993. Potatoes were irrigated with ECw 1.2 dS/m (National Water Carrier) and ECw 6.2 dS/m (Local Well) water at three frequencies: 1 time/day, 3 times/day, and 6 times/day. A series of physiological and growing determination and salt accumulation measurement of the soil under drip irrigation were conducted during the trial. It was found that saline water irrigation reduced potato production by 12% compared with fresh water irrigation at the frequency of 1 time/day, while there were no significant differences between saline and fresh water irrigation at frequencies of 3 times/day and 6 times/day. However, saline water increased tuber weight and dry weight ratio. Plant height, growth and dry matter accumulation of potatoes decreased in case of saline water irrigation. Potatoes of high yield and quality can be produced on sand dunes only by adequate irrigation. We believed that the high permeability of sandy soli could allow the use of saline water with drip irrigation, thus, the natural resources (water and nutrients) can be controlled for the requirement of plant growth.