In this paper, the research of regional sustainable development in Guilin City was carried out. The study included the following: 1)Prediction of the development and change of regional PRESD system factors and their relationships; 2) Evaluation of the sustainability of regional PRESD system development Results showed that in the regional sustainable development in Guilin City,some senous problems will be faced in the future. It is important to study and predict the factors affecting the regional sustainable development. Thus. land resources and their use were taken as core of the study on the regional Sustainable development which will promote sustainable development study into practice stage and enrich the research theories and methods. In the end of this paper, some countermeasures for regional sustainable development in Guilin City were put forward, and the methods in regional sustainable development research were discussed.