A batch equilibrium experiment was carried out to study adsorption and desorption of Chlortetracycline (CTC) in four types of soils, namely Ustic Cambosols collected form Fengqiu of Henan, Udic Argosols collected from Nanjing of Jiangsu, Gleyic-Stagnic Anthrosols collected from Changshu of Jiangsu and Ali-Perudic Ferrosols collected from Yingtan of Jiangxi. Results show that the linear model is not appropriate to describe any of the experimental sorption-desorption data, while the Freundlich model and the Langmuir model fit pretty well. Different sorption behaviors of Chlortetracycline were observed in the four tested soils, with K_f values varying sharply, 1 135 L kg^-1 for Cambosols; 1 250 L kg^-1 for Argosols; 2 618 L kg^-1 for Anthrosol; and 4 315 L kg^-1 for AliHaplic Acrisol. The apparent sorption/desorption hysteresis was quantified for each sample. It had been observed that K_f values are in a significantly negative correlation with soil pH.