Abstract: Samples of a variety of environmental media, such as soil (n=151), groundwater (n=9), air (solid PM₁₀ and gaseous PCBs, n=4), vegetable (n=38) and rice (n=95) were collected in a typical area for analysis of concentrations of PCBs and Cd. The carcinogenic exposure dose and risk of PCBs and Cd to people living in that environment and being exposed to the multi-media through multi-pathway were assessed, using the carcinogenic risk assessment model of USEPA. Contribution rate of the pollutants to the carcinogenic risk was analyzed. And main carcinogenic contaminants, exposure pathways and the greatest contributor among the environmental media to the carcinogenic risk were screened out. Results show that all the investigated media were heavily polluted by PCBs and Cd. The concentration of Cd in the vegetable and rice reached 130 and 17 times the threshold value for the pollutants in the food of China, respectively. Both PCBs and Cd in the groundwater were high in over-limit ratio. The gaseous PCBs and the PM10-borned PCBs and Cd were all higher in this area than in other areas in and out of the country. The assessment of carcinogenic exposure dose indicates that the total carcinogenic exposure dose of PCBs and Cd is 6.8 and 6.1 times as high as the acceptable daily intake, respectively. The total carcinogenic risk was 1.1*10_-3, much higher than the acceptable carcinogenic risks stipulated by other countries and regions. The analysis of carcinogenic contribution rate suggests that oral ingestion was the main pathway of exposure to the carcinogenic risk. Vegetable, rice and groundwater were the main sources of carcinogenic PCBs and Cd in this area.