Karst areas at different vegetation restoration stages were studied with slope farmland and artificial forest as control using the approach of substituting the temporal serial with spatial serial. And further through lab analysis using the principle component analysis method, variation of soil anti-erodibility was explored. Results show that the contents of soil organic matter, <0.001 mm clay, >0.25 mm water-stable aggregates and <0.05 mm silty clay and the structural particle index were optimal indicators for evaluating soil anti-erodibility. In terms of comprehensive anti-erodibility index, the lands at different vegetation restoration stages mixture of frutex and meadow thicket > mixture of arbor and frutex > frutex > arbor > artificial Chinese Cryptomeria stand > meadow thicket > slope farmland. Slope farmland was the lowest in soil anti-erodibility in the karst region. During the process of vegetation restoration, soil anti-erodibility improved and then deteriorated with the stage of mixture of frutex and meadow thicket as turning point, suggesting that, the model of mixture of frutex and meadow thicket is appropriate to vegetation restoration in karst regions.