In the work, the reason of ginseng red skin sickness in albic soil were studied by the ecological quadrat methods. Results showed that active reducing organic substances could form in bed soil under moisture capacity and well aerated conditions, and they promoted the activation of iron and manganese oxides and enhanced the accumulation of divalent iron and manganese. Ginseng red skin sickness could be attributed to the oxidizing and depositing of ferrous iron in epidermis of ginseng root or to the protective reaction of ginseng root to poisonousnss of ferrous ions. The results also showed that divalent manganese inhibited ginseng red skin sickness. In the bed soil, active reducing substances is the induced factor and ferrous ions is the leading factor in the occurrence of ginseng red skin sickness.