Pot experiments were carried out to evaluate effects of soil amendments on heavy metal uptake and distribution in different organs of tobacco plants, which were planted in soil containing Pb 330 mg kg^-1 and Cd 1 mg kg^-1 of extraneous sources. Three different kinds of soil amendments were applied separately, Pb and Cd contents in and biomasses of different parts of the plants during different growth periods were investigated to determine effects of the amendments on heavy metal uptake by the tobacco. The results show that the translocation factor (TF) of Pb is lower than that of Cd, indicating that Cd in tobacco moved more easily than Pb. Cd in the tobacco leaves is more harmful to human health than Pb; Compared with control, pots treated with amendments had more Cd and Pb left in the soil, suggesting that all the three kinds of soil amendments more or less reduced Cd and Pb contents in different parts of the tobacco plants, and increased biomass of the tobacco. Therefore, they had positive effects on tobacco growth and reduction of Pb and Cd uptake by tobacco. Among all the amendments, attapulgite was the best modifier, and bone powder was better than activated carbon.