At present,most of studies about the two-region model(TRM)are all focused on modeling solute transport in laboratory short soil column at small scale. The objective of this study was to investigate the validity and parameters of the two-region model(TRM)describing solute transport across a long range of travel distances in heterogeneous soil. We used the TRM, the convection-dispersion equation(CDE)and the fractional advection-dispersion equation(FADE)to characterize the solute transport process in a 1250-cm long one-dimensional heterogeneous soil column. Comparing to CDE and FADE,the break-through curves(BTCs)at different travel distances can be better fitted by using TRM,and TRM is better to capture the full evolution of the BTCs,especially for the early and long tailing part. It implies that TRM is a highly effective approach to describe the evolution of solute transport at relatively large-scale domain in heterogeneous soil. We found that TRM had similar scale-depen-dent dispersion as CDE. However,the dispersion coefficient of TRM was less scale-dependent than that of CDE. It was also found that the mass transfer coefficient of TRM decreased with the advection time in a power law function indicating the presence of multiple timescales of solute mass transfer between immobile and mobile regions,and the mobile water fraction of TRM can be determined with the ratio of effective porosity and total porosity of soil.