The composition and distribution of mineral, major elements and rare earth elements (REE) in the granodiorite weathering crust in Antoun area in Attapeu Province of PDR of Lao was determined by means of rock thin section, XRD, XRF and ICP-MS etc. Results show all the samples, except for granodiorite, are acid. There is a thin siliceous crust on the top soil of the weathering profile. Quartz content reaches the highest in top soil where kaolinite and iron oxide contents are lower than layer under it. These are some typical characteristics of Spodosols. With intensifying weathering reaction, Fe₂O₃, TiO₂ and Al₂O₃ are enriched, and Na₂O, CaO and MgO, K₂O are leached in weathering material. It is assumed that some clay minerals in the top soil are washed away by rainfall and leached by acid solution in wet season, and that SiO₂ moves up to the top soil from the lower layers in dry season. The Chondrite normalized REE pattern shows typical enrichment of LREE, with ∑REE peaking up to 318 mg kg^-1 in central layer of the profile. Both Ce and Eu have a similar trend of variation in the profile, i.e. positive anomalynegative anomalypositive anomaly from bottom to top The highest ∑REE value occurs where negative Ce and Eu anomaly and relatively higher Fe²⁺/Fe³⁺ values also occur. Furthermore, there is a relatively significant correlation between ∑REE and Fe₂O₃ throughout the whole profile, reflecting that REE enrichment is related to adsorption of iron-aluminum oxides and relatively reductive-acid environment.