In recent years, the pollution of heavy metals and organic pollutants in site soil-groundwater in China is very prominent, which has become one of the important problems to be solved urgently. Multi-medium interface is the key to control the environmental behavior of complex pollutants in site system. Therefore, the development of the multi-medium interface process and regulation mechanism of pollutants in site soil-groundwater is very important for understanding the causes of site pollution and remediation. This paper systematically analyzes the research progress and development trend of multi-medium interface process and regulation of pollutants in soil-groundwater at home and abroad, points out the scientific and technical problems to be solved in this field, and puts forward the research ideas and main directions of the multi-medium interface process and regulation mechanism of pollutants in site soil-groundwater in China, which will promote the development of soil and groundwater environmental science and technology in China.