【Objective】Yunnan Province is one of the typical high geological background regions in China. However, a few studies have focused on the phytoextraction of high geological soils for safe agricultural production. 【Method】This research was conducted to investigate cadmium (Cd) phytoextraction efficiency of the high geological background soils from Shilin, Fuyuan, and Luoping in Yunnan Province by the Cd/zinc (Zn) hyperaccumulator Sedum plumbizincicola and its effect on plant growth and Cd uptake by rice (Oryza sativa) through pot experiments. 【Result】After triple-cropping of S. plumbizincicola, the total Cd and available Cd concentrations in soils showed a substantial decrease, with the total Cd decreasing to 24.8%, 30.9%, and 58.8% of the original values for soils from Shilin, Fuyuan, and Luoping, respectively. S. plumbizincicola showed better growth when grown in soils from Fuyuan developed from basalt with more soil nutrients but presented a greater Cd phytoextraction efficiency when grown in soils from Shilin developed from limestone with higher soil pH, thereby greater Cd mobilization capacity. These significant differences indicated that plant growth and heavy metal accumulation of hyperaccumulators were affected by the comprehensive effects of soil parent materials, soil nutrients, and heavy metal availability in soils. After a triple-cropping of S. plumbizincicola, Cd concentration in brown rice and rice straw was significantly decreased under flooding conditions through the whole growth period, resulting in a Cd-safe production. However, the rice grain possessed a high Cd pollution risk without phytoextraction when grown under a dry cultivation system. 【Conclusion】The phytoextraction of high geological background soils by S. plumbizincicola combing with water management measures benefits greatly the safe production of rice crops, thereby providing a theoretical basis and technical support for the safe production of the high geological background soils.