Soil is the main natural resource for human survival and development. In recent years, the aquatic risks induced by the tire rubber antioxidant N-(1, 3-dimethylbutyl-N'-phenyl-p-phenylenediamine (6PPD) and its ozonated derivative N-(1, 3-dimethylbutyl-N'-phenyl-p-benzoquinone (6PPD-Q) are causing global concern. However, little is known about their behavior in soil and the effects on soil biota. Evidence have shown that soil is an important "aggregation" of tire wear particles (TWPs), and the TWPs entering the environment release various species of additives including rubber antioxidants, silica, metals, etc. Among them, p-Phenylenediamines (PPDs) are the most widely added rubber antioxidants due to their excellent performance, which can be released as TWPs into environmental media and produce derivatives such as PPD-Qs. Therefore, it is of great significance to study the fate and ecological environmental risks of 6PPDs and their derivatives in soil. Focusing on their soil environmental safety and ecological health, we introduce the behavioral characteristics of the occurrence, migration, and transformation of 6PPD and 6PPD-Q in the soil environment; describe the accumulation, transport, and metabolism mechanisms of 6PPD and 6PPD-Q in terrestrial organisms; and elucidate their toxicological characteristics and the related toxicity mechanisms on organisms. It provides a theoretical basis for the ecological risk assessment and prevention of 6PPD and 6PPD-Q pollution.