【Objective】The environmental footprint assessment of in-situ chemical oxidation remediation technology (ISCO) for polluted sites has important scientific research value and practical significance for promoting green and sustainable remediation. However, its application in chlorinated hydrocarbon-contaminated sites has not received much attention. 【Method】 This study employed the ISCO method to remediate a chlorinated hydrocarbon-contaminated site. The remediation of polluted sites using ISCO is divided into four stages: material consumption, transportation process, remediation process, and sampling testing. SiteWiseTM tool was used to conduct an environmental footprint assessment. 【Result】The results showed that using ISCO technology to remediate 73 800 cubic meters of polluted aquifers resulted in 1 261 tons of greenhouse gas (GHG) emissions, total energy consumption of 16 876 GJ, 4 096 kg of SOx emissions, 2 678 kg of NOx emissions, and 912 kg of particulate matter 10 (PM10) emissions. The environmental footprint mainly came from the use of materials such as sodium persulfate and sodium hydroxide, and the consumption of construction electricity caused higher atmospheric pollutant emissions. The Monte Carlo analysis results indicated that the coefficient of variation of greenhouse gas emissions was less than 10%. Also, the sources of uncertainty in this study mainly included redundant designs from ISCO, as well as significant differences in mechanical efficiency and emission factors between different countries. 【Conclusion】The SiteWiseTM tool has reference value for the environmental footprint assessment of ISCO remediation projects in polluted sites in China and future researchers should update it locally by considering machinery types and efficiencies, emission factors, and units of measurement. These considerations will improve applicability to the environmental footprint assessment of polluted sites in China.