【Objective】Coastal wetlands serve as crucial "blue carbon" sinks for mitigating climate change, while they also represent significant sources of marine methane (CH₄) emissions. However, the impacts of multiple climate change factors on CH₄ emissions from coastal wetlands has not been systematically evaluated. 【Method】This study integrated 241 observational datasets from 41 peer-reviewed papers published between 1995 and 2025, and comprehensively analyzed the effects of elevated atmospheric CO₂ concentration (eCO₂), warming and sea level rise(SLR) on the CH₄ emissions from coastal wetlands.【Result】The results indicated that eCO₂ increased CH₄ emissions by an average of 33.26%, but had no significant effect on wetlands dominated by C4 plants. Furthermore, prolonged eCO? exposure was found to attenuate its stimulatory effect on CH? emissions. Warming increased CH₄ emissions by 58.15% on average. The promoting effect was stronger with greater warming magnitudes, and active warming had a more pronounced effect than passive warming. Nitrogen addition significantly weakened the stimulatory effect of warming on CH₄ emissions. SLR exerted the most pronounced stimulatory effect on CH? emissions, with an increase of 112.85%, which was significantly negatively correlated with salinity. Additionally, the interactive effect of warming and SLR significantly enhanced CH? emissions, with a response magnitude markedly higher than that under warming alone.【Conclusion】Overall, eCO₂, warming, and SLR as individual drivers significantly enhanced CH₄ emissions from coastal wetlands, but the magnitude of their effects was regulated by both biotic and abiotic factors, and interactions among climate drivers were highly complex. Therefore, future studies should prioritize multifactorial simulation experiments to elucidate how multiple climate change drivers and their interactions synergistically regulate CH? emissions through biotic and abiotic pathways, thereby improving predictions of greenhouse gas feedbacks from coastal wetlands under ongoing climate change.