Spat ial variability and regionalized management technology of soil nutrients in a grain crop region with an area of 470 km² was studied using geo-statistics.The results showed that the grain crop region was widely deficient in N,P,K,Mn and Zn.Variation of the soil nutrients differed remarkably.The maximum correlative distance of major soil N,P,K,Mn and Zn in content was 27.1,19.7,27.1,14.4 and 26.4 km,respectively.It revealed that their variation in content developed in large block scale,which is useful to regionalized management of soil nutrients.There was a notable tendency of soil readily available nutrients in spatial distribution in the grain crop region.The grain crop region could be regionalized into 2 to 3 management units,and each unit consisted of connected fields.The number of management units in the grain crop region were 2 for N,3 for P,3 for K,3 for Mn,2 for Zn.With regionalized balance fertilization technology on wheat and corn,yield increased by 10.9% to 13.1% and 14.3% to 21.7%,respectively,economic profit by 590 to 747 and 724 to 1343 RMB Yuan hm^-2.