A soil incubation experiment was conducted to investigate effects of application of nitrogen (N), phosphorus (P) and potassium (K) fertilizers on availability of soil Cd. Results show that after 60 days of incubation, all the N fertilizer treatments lowered soil pH, and increased the amount of extractable Cd; among them urea of high rate and ammonium chloride displayed the most significant effects, and ammonium sulfate did the least in increasing extractable Cd. All the P fertilizer treatments caused modest reduction of soil pH, but in terms of their effect of increasing extractable Cd, only single superphosphate showed something significant. All the three K fertilizer treatments reduced soil pH; among them potassium chloride increased extractable Cd the most at D0, but the effect waned down after D15. At the end of the experiment, the contents of extractable Cd in all the K fertilizer treatments fell below that in CK. The findings further suggest that it is advisable to avoid application at a high rate of acidic fertilizers, such as urea (after its transformation), ammonium chloride and single superphosphate, and other acidic materials as well, to soils severely polluted with Cd or soils with Cd content close to the threshold value of pollution, and use di-ammonium phosphate and ammonium sulfate instead.