[Objective] The Huang-Huai-Hai plain is one of the most important agricultural production bases in China. Nevertheless, there exists very little information on the current status of soil organic matter content in cultivated land across this area or on the in-depth analysis of spatial distribution characteristics for regional soil organic matter management.[Method] Based on the spatial autocorrelation theory and soil property data from 267 sample sites, this study investigated the spatial distribution structures of soil organic matter content in dry farmlands in the Huang-Huai-Hai plain and analyzed the spatial autocorrelations between organic matter and soil clay particle content/soil bulk density.[Result] The results showed that the regional average values of soil organic matter contents of dry farmlands in the Huang-Huai-Hai plain were 20.11±6.46(0~10 cm), 14.76±5.11(10~20 cm), 9.96±4.14(20~30 cm), and 8.03±3.45(30~40 cm)g·kg^-1, which corresponded to levels 3 to 5. In the soil layers between 0~10 cm and 10~20 cm, the high-value areas were mainly distributed in the traditional agricultural production areas such as Piedmont plain of Taihang Mountain, and Yellow River Irrigation Area in Shandong, and lime concretion black soil areas in southern Henan and northern Anhui also included. As the depth of the soil layer increased, the spatial distribution structure of soil organic matter content became obvious. In the soil layers between 10~20 cm, 20~30 cm, and 30~40 cm, the Hebei plain and Northwestern Shandong showed LL(Low-Low)and HL(High-Low)distribution characteristics while Henan and Anhui regions mainly demonstrated HH(High-High)and LH(Low-High)type distributions. The specific distribution of spatial autocorrelation types in the different soil layers was different. Also, the mathematical relationship between the contents of soil organic matter and clay particles was significant(P<0.05), but there was no significant difference in the relationship between organic matter content and soil bulk density. Among the two-variable local spatial autocorrelation types; organic matter/clay particle content and organic matter/bulk density, (i)the LL/HL types were mainly distributed in Hebei plain and Northwestern Shandong region; (ii)the HL type was concentrated in the Piedmont plain of Taihang Mountain and Yellow River Irrigation Area in Shandong for 0~10 cm and 10~20 cm soil layers; and(iii)the HH/LH types were mainly distributed in Henan and Anhui, with a distinct distribution in the different soil layers.[Conclusion] Soil organic matter content in dry farmlands in the Huang-Huai-Hai plain showed apparent spatial autocorrelation characteristics. The spatial autocorrelation structure between soil organic matter content and clay content was more distinct. Importantly, the spatial autocorrelation structure in 0~10 cm and 10~20 cm soil layers was more obvious than that in 20~30 cm and 30~40 cm soil layers. The observed dissimilarities in distribution structure in the spatial horizontal and vertical soil layering directions were attributed to regional differences in agricultural management.